Acromegaly and Its Clinical Outcomes: A 10-year Retrospective Analysis of a Cohort of Patients with Acromegaly from a University Setting

Objective: We purpose to evaluate the demographic characteristics of patients with acromegaly, laboratory values when diagnosed and during follow-up, clinical symptoms, comorbid conditions treatment methods, response rates. Methods: Data regarding 71 acromegaly who applied Karadeniz Technical University Faculty Medicine Endocrinology Metabolic Diseases polyclinic outpatient setting between 2010 2020 were included in study. The patients' characteristics, values, features selected methods examined retrospectively. Results: A total was eligible, which 45.1% female, 54.9% male. mean age at diagnosis 48.5 years. most common complaint an enlargement hands feet (53.5%). 35.2% had hypertension, 23.9% diabetes mellitus (DM), 1.4% cardiovascular disease, 5.6% a malignancy history. In diagnosis, 2.8% secondary adrenal insufficiency, hypothyroidism, 7% hypogonadism, panhypopituitarism. Pituitary determined 97.2% patients, non-pituitary 2.8%. Regarding co-morbid conditions, Of pituitary adenoma, 71% macroadenoma, 29% microadenoma. adenoma size 15.3±7.8 mm. Surgery preferred primary 76.1% surgery. 40.8% ononly surgical applied, while surgery+ medical treatment, 8.5% only surgery +medical + radiotherapy, chemotherapy. After all treatments, 49.3% remission. follow-ups, colon 4.2% thyroid 5.6%. Conclusions: our study, tThe generally similar those literature. It evident that early initiation, patient prominent factors decreasing comorbidities.